As a service to physicians, researchers, patients, and families, the registry has compiled a list of selected peer-reviewed references related to dipg. this list is for information only. the registry does not endorse or recommend any of the specific conclusions or approaches to therapy described.
Abstracts and additional information available by selecting the links to PubMed.gov, a service of the US National Library of Medicine and the National Institutes of Health.
Title Phase Recruitment Conditions Interventions Sponsors Expected Completion Date
International Diffuse Intrinsic Pontine Glioma (DIPG) Registry and Repository Observational Recruiting Diffuse Intrinsic Pontine Glioma Cincinnati Children's Hospital Medical Center June 2037
Convection-Enhanced Delivery of 124I-8H9 for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy Phase I Recruiting Brain Cancer|Brain Stem Glioma Radiation: Radioactive iodine-labeled monoclonal antibody 8H9 Memorial Sloan-Kettering Cancer Center|Weill Medical College of Cornell University|Johns Hopkins University December 2016
An Investigational Immuno-therapy Study of Nivolumab Monotherapy and Nivolumab in Combination With Ipilimumab in Pediatric Patients With High Grade Primary CNS Malignancies (CheckMate 908) Phase 2 Recruiting Diffuse Intrinsic Pontine Glioma (DIPG) Biological: Nivolumab Biological: Ipilimumab Bristol-Myers Squibb June 14, 2021
PNOC 007: H3.3K27M Peptide Vaccine for Children With Newly Diagnosed DIPG and Other Gliomas Phase 1 Recruiting Diffuse Intrinsic Pontine Glioma, Glioma Biological: K27M peptide University of California, San Francisco; The V Foundation for Cancer Research; Pacific Pediatric Neuro-Oncology Consortium November 2020
Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma Early Phase 1 Recruiting Diffuse Intrinsic Pontine Glioma Drug: Gemcitabine University of Colorado, Denver September 2018
Oncolytic Adenovirus, DNX-2401, for Naive Diffuse Intrinsic Pontine Gliomas Phase 1 Recruiting Brainstem Glioma Biological: DNX-2401 Clinica Universidad de Navarra, Universidad de Navarra August 30, 2019
ADVL1217: WEE1 Inhibitor AZD1775 and Local Radiation Therapy in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas Phase 1 Recruiting Diffuse Intrinsic Pontine Glioma Untreated Childhood Anaplastic Astrocytoma Untreated Childhood Anaplastic Oligoastrocytoma Untreated Childhood Glioblastoma Untreated Childhood Gliosarcoma Drug: WEE1 Inhibitor AZD1775 National Cancer Institute (NCI) October 2021
Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication (BIOMEDE) Phase 2 Recruiting Diffuse Intrinsic Pontine Glioma Drug: Erlotinib Drug: Everolimus Drug: Dasatinib Gustave Roussy, Cancer Campus, Grand Paris; Innovative Therapies For Children with Cancer Consortium October 2018
Administration of Ribociclib Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG) Phase 1 Phase 2 Recruiting High Grade Glioma, Diffuse Intrinsic Pontine Glioma, Bithalamic High Grade Glioma Drug: Ribociclib Cincinnati Children's Hospital Medical Center January 2018
PNOC 009: CED With Irinotecan Liposome Injection Using Real Time Imaging in Children With DIPG Phase 1 Recruiting Diffuse Intrinsic Pontine Glioma Drug: Convection Enhanced Delivery (CED) of Nanoliposomal irinotecan University of California, San Francisco June 2019
PBTC-047 Trial of Panobinostat in Children With Diffuse Intrinsic Pontine Glioma Phase 1 Recruiting Glioma Drug: LBH589 (Panobinostat) Pediatric Brain Tumor Consortium February 2019
Pediatric MATCH Phase 2 Recruiting Malignant Glioma, Recurrent Central Nervous System Neoplasm, Recurrent Glioma Drug options: Ensartinib, Larotrectinib, Olaparib,pan-FGFR Tyrosine Kinase Inhibitor JNJ-42756493 PI3K/mTOR Inhibitor LY3023414,Selumetinib Sulfate, Tazemetostat, Vemurafenib National Cancer Institute (NCI) December 31, 2021
Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 Phase 1 Phase 2 recruiting Glioblastoma Multiforme Fibrillary Astrocytoma of Brain Glioma of Brainstem Anaplastic Astrocytoma Pilomyxoid Astrocytoma Mixed Oligodendroglioma-Astrocytoma Brain Stem Glioma Diffuse Intrinsic Pontine Glioma Erbitux and Bevacizumab Weill Medical College of Cornell University January 2018
Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, or Hypermutated Brain Tumors Phase 1 Recruiting Malignant Glioma, Recurrent Brain Neoplasm, Recurrent Diffuse Intrinsic Pontine Glioma, Refractory Brain Neoplasm, Refractory Diffuse Intrinsic Pontine Glioma Biological: Pembrolizumab National Cancer Institute (NCI) April 1, 2018
Re-Irradiation of Progressive or Recurrent DIPG Recruiting Recurrent or Progressive Diffuse Intrinsic Pontine Glioma Radiation: re-irradiation University of Calgary October 2021
GSK MEK116540: Study to Investigate Safety, Pharmacokinetic (PK), Pharmacodynamic (PD) and Clinical Activity of Trametinib in Subjects With Cancer or Plexiform Neurofibromas and Trametinib in Combination With Dabrafenib in Subjects With Cancers Harboring V600 Mutations Phase 1 Recruiting Solid including primary brain tumors and DIPGs Drug: Trametinib, Drug: Dabrafenib GlaxoSmithKline September 2017
Study of the Combination of Crizotinib and Dasatinib in Pediatric Research Participants With Diffuse Pontine Glioma (DIPG) and High-Grade Glioma (HGG) Phase 1 Recruiting Diffuse Intrinsic Pontine Glioma, High-grade Glioma Drug: Crizotinib, Drug: Dasatinib St. Jude Children's Research Hospital September 2017
Study of Suberoylanilide Hydroxamic Acid (SAHA) With Temsirolimus in Children With Diffuse Intrinsic Pontine Glioma (DIPG) Phase 1 Recruiting Diffuse Intrinsic Pontine Glioma Drug: Vorinostat Radiation: Radiation Therapy Drug: Temsirolimus M.D. Anderson Cancer Center October 2018
Prolonged Exposure to Doxorubicin in Patients With Glioblastoma Multiforme and Diffuse Intrinsic Pontine Glioma Phase 2 Recruiting Glioblastoma (GBM); DIPG Drug: Doxorubicin Meyer Children's Hospital July 2020
Safety Study of DIPG Treatment With Autologous Dendritic Cells Pulsed With Lysated Allegenic Tumor Lines Phase 1 Recruiting Diffuse Intrinsic Pontine Glioma Biological: Autologous dendritic cells Fundació Sant Joan de Déu; Institut d'Investigacions Biomèdiques August Pi i Sunyer March 2019
PNOC 003: Molecular Profiling for Individualized Treatment Plan for DIPG Phase 1 Recruiting Diffuse Intrinsic Pontine Glioma (DIPG) Other: Specialized tumor board recommendation Radiation: Standard radiation therapy University of California, San Francisco December 2016
A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas Phase 1 Phase 2 Recruiting Pilomyxoid Astrocytoma Pilocytic Astrocytoma Glioma, Astrocytic Optic Nerve Glioma Pleomorphic Xanthoastrocytoma Glioblastoma Multiforme Anaplastic Astrocytoma Gliosarcoma Diffuse Intrinsic Pontine Glioma DIPG Low-grade Glioma Brainstem Glioma Drug: Mebendazole Drug: Vincristine Drug: Carboplatin Drug: Temozolomide Drug: Bevacizumab Drug: Irinotecan Mark Atlas; Janssen Pharmaceuticals; Northwell Health April 2018
Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors Phase 1 Recruiting Diffuse Intrinsic Pontine Glioma Brain Tumor, Recurrent Solid Tumor, Recurrent Neuroblastoma, Recurrent, Refractory Ewing Sarcoma, Recurrent, Refractory Rhabdomyosarcoma, Recurrent, Refractory Osteosarcoma, Recurrent, Refractory Rhabdoid Tumor, Recurrent, Refractory Drug: Abemaciclib Children's Healthcare of Atlanta/Emory University October 2018
Wild-Type Reovirus in Combination With Sargramostim in Treating Younger Patients With High-Grade Recurrent or Refractory Brain Tumors Phase 1 Recruiting Astrocytoma Childhood Atypical Teratoid/Rhabdoid Tumor Diffuse Intrinsic Pontine Glioma Glioma Recurrent Childhood Anaplastic Oligodendroglioma Recurrent Childhood Brain Neoplasm Recurrent Childhood Glioblastoma Recurrent Childhood Medulloblastoma Recurrent Primitive Neuroectodermal Tumor Refractory Brain Neoplasm Biological: Sargramostim Biological: Wild-type Reovirus Mayo Clinic April 2020
Molecular Analysis of Samples from Patients with Diffuse Intrinsic Pontine Glioma and Brainstem Glioma Observational Recruiting Diffuse Intrinsic Pontine Glioma|Brainstem Glioma Not applicable Children's Research Institute April 2016