Current Research Projects
Ongoing Research Projects:
- Establishment of Intra-brain Stem Xenograft Mouse Models and Permanent Cell Cultures of DIPG
- Patterns of cerebrospinal fluid diversion and survival in children with diffuse intrinsic pontine glioma
- Diffuse Intrinsic Pontine Glioma (DIPG): the Australian Experience
- Re-irradiation of children with DIPG: practices and outcomes
- Characterizing temporal genomic heterogeneity in pediatric DIPG
- Elucidating lipid metabolic reprogramming in Diffuse Intrinsic Pontine Glioma
- Novel target discovery in Diffuse Midline Glioma
- Outcomes for children with spinal diffuse midline gliomas (sDMG): a DIPG Registry Study
- Clinical, Radiological, Histological, and Molecular Characteristics of Patients with Midline Gliomas in Canada
- Timing of Radiation Therapy Initiation and Association with Neurological Recovery in Patients with New Diagnosis of DIPG
- Evaluation of the distribution and correlates of post-radiation and best responses over time in patients with diffuse intrinsic pontine glioma (DIPG): A IDIPGR Study
- Clinical, Radiographic, Histopathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma-an Update from the International and European Society for Pediatric Oncology DIPG Registries
- Initial and early metastatic spread in diffuse midline glioma, H3 K27-altered; Potential implications for diagnostic workup and treatment
- Racial and Ethnic Biases in Patients enrolled in the International DIPG/DMG Registry: Addressing demographic representativeness and barriers to research participation
- Comprehensive untargeted metabolomics profiling of diffuse midline glioma for biomarker discovery and therapeutic targets
- Using AI to help with diagnosis, volumetric analysis and the molecular classification of primary pediatric CNS Tumors
- Predicting Early Death in Children diagnosed with Diffuse Midline Glioma
Completed Research Projects:
- Comprehensive Molecular-Based Cross-Species Comparison of DIPG Biology
- Radiogenomic Evaluation of Radiation Resistance in Diffuse Intrinsic Pontine Glioma
- A safety run-in, phase 2 trial of Convection Enhanced Delivery (CED) of Carboplatin and Sodium Valproate into the pons for the treatment of Diffuse Intrinsic Pontine Glioma (DIPG) after radiotherapy in children aged 3-17 years
- STAT3 expression in patients with diffused intrinsic pontine glioma
Manuscripts Published:
- Determining predictive factors of survival through clinicopathologic, genomic and radiographic analysis of infants < 3 years of age with Diffuse Intrinsic Pontine Glioma: A study from the International DIPG Registry
- Defining Volumetric Endpoints for Tumor Response in Diffuse Intrinsic Pontine Glioma
- Retrospective assessment of the RAPNO DIPG criteria on a sample of patients from the DIPG Registry
- Non-DIPG Patients Enrolled in the International DIPG Registry: Histopathologic Evaluation of Central Neuro-Imaging Review
- Pediatric Brain Tumor Segmentation Challenge (BRaTS-PED Challenge)
- Characteristics of Patients ≥ 10 Years of Age with Diffuse Intrinsic Pontine Glioma: A Report from the International DIPG Registry
- MR Imaging Features of Diffuse Intrinsic Pontine Glioma (DIPG) and Relationship to Overall Survival: Report From the International DIPG Registry
- Medulloblastoma therapy generates risk of a poorly-prognostic H3 wild-type subgroup of diffuse intrinsic pontine glioma: a report from the International DIPG Registry
- The International Diffuse Intrinsic Pontine Glioma Registry: an infrastructure to accelerate collaborative research for an orphan disease
- Development of the SIOPE DIPG Network, Registry and Imaging Repository: A collaborative effort to optimize research into a rare and lethal disease
- Contemporary Survival Endpoints: An International Diffuse Intrinsic Pontine Glioma Registry Study
- External validation of the diffuse intrinsic pontine glioma survival prediction model: a collaborative report from the International DIPG Registry and the SIOPE DIPG Registry
- Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries
To submit a research proposal please contact the Registry office.
Or access the application here.
