Despite our improved biologic understanding, therapeutic translation to improve survival in DIPG remains a significant hurdle and represents a profoundly unmet need in pediatric neuro-oncology. The international DIPG Registry was created to provide a database of demographic, clinical, radiologic, and pathologic data, as well as a bioinformatics repository of molecular data of DIPG patients across the world. The long-term objective of this registry is to establish and maintain a hypothesis-driven research infrastructure that will support a wide spectrum of interdisciplinary and translational projects to study DIPG. Data collected will form a research continuum from basic biology to clinical practice that will ultimately address our primary goals to accomplish improved understand the biology of DIPG, development of more effective targeted therapies, and development of novel approaches for uniform diagnosis, classification, response assessment, and multidisciplinary treatment and follow-up that will improve survival and care of patients with DIPG.