As a service to physicians, researchers, patients, and families, the registry has compiled a list of selected peer-reviewed references related to dipg. this list is for information only. the registry does not endorse or recommend any of the specific conclusions or approaches to therapy described.
Abstracts and additional information available by selecting the links to PubMed.gov, a service of the US National Library of Medicine and the National Institutes of Health.
Year Abstract Authors Journal Volume, Issue, & Page Numbers
2017 Therapeutic targeting of histone modifications in adult and paediatric high grade glioma MJ Williams, WGB Singleton, K Malik, SP Lowis et al. Frontiers in Oncology Epub ahead of print
2017 New therapeutic targets for diffuse intrinsic pontine glioma Charlotte Ridler Nature Reviews Neurology Epub ahead of print
2017 Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors S Gholamin, SS Mitra, AH Feroze, J Liu, SA Kahn et al. Science Translational Medicine Vol. 9, Issue 381
2017 Convection-Enhanced Delivery Mehta, A.M., Sonabend, A.M. & Bruce Neurotherapeutics Epub ahead of print
2017 Plasma and cerebrospinal fluid pharmacokinetics of select chemotherapeutic agents following intranasal delivery in a non-human primate model James C. League-Pascual,Cynthia M. Lester-McCully,Shaefali Shandilya,Lukas Ronner,Louis Rodgers,Rafael Cruz,Cody J. Peer,William D. Figg,Katherine E. Warren Journal of Neuro-Oncology Epub ahead of print
2017 Glioma Subclassifications and Their Clinical Significance Chen, R., Smith-Cohn, M., Cohen, A.L. et al. Neurotherapeutics Epub ahead of print
2017 Therapeutic Potential for Bone Morphogenetic Protein 4 in Human Malignant Glioma G Xi, B Best, B Mania-Farnell, CD James, T Tomita Neoplasia Mar 6;19(4):261-270
2017 Second re-irradiation for DIPG progression, re-considering “old strategies” with new approaches AM La Madrid, V Santa-María, OC Martinez et al. Child's Nervous System Epub ahead of print
2017 Robot-assisted stereotactic biopsy of Diffuse Intrinsic Pontine Glioma: a single centre experience A Carai, A Mastronuzzi, A De Benedictis, R Messina et al. World Neurosurgery Epub ahead of print
2017 The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas Jane L. Anderson,Ranjithmenon Muraleedharan,Nicole Oatman,Amanda Klotter, Satarupa Sengupta, Ronald R. Waclaw, Jianqiang Wu, Rachid Drissi, Lili Miles, Eric H. Raabe, Matthew L. Weirauch, Maryam Fouladi, Lionel M. Chow, Lindsey Hoffman, Mariko DeWire, and Biplab Dasgupta Neuro-Oncology Epub ahead of print
2017 EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas Faizaan Mohammad, Simon Weissmann, Benjamin Leblanc, Deo P Pandey, Jonas W Højfeldt et al. Nature Medicine Epub ahead of print
2017 Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas Andrea Piunti, Rintaro Hashizume, Marc A Morgan, Elizabeth T Bartom et al. Nature Medicine Epub ahead of print
2017 Neuronal Activity in Ontogeny and Oncology H Venkatesh, M Monje Trends in Cancer Volume 3, Issue 2, p89–112, February 2017
2017 Preclinical evaluation of convection-enhanced delivery of liposomal doxorubicin to treat pediatric diffuse intrinsic pontine glioma and thalamic high-grade glioma ACP Sewing, T Lagerweij, DG van Vuurden, MH Meel et al. Journal of Neurosurgery Epub ahead of print
2017 Targeting Epigenetic Pathways in the Treatment of Pediatric Diffuse (High Grade) Gliomas MI Vanan, DA Underhill, DD Eisenstat Neurotherapeutics Epub ahead of print
2017 Glioblastoma spheroids produce infiltrative gliomas in the rat brainstem Zhiping Zhou,Neal Luther,Ranjodh Singh,John A. Boockvar,Mark M. Souweidane,Jeffrey P. Greenfield Child's Nervous System Epub ahead of print
2017 Tissue sampling in diffuse intrinsic pontine glioma (DIPG) at progression A Castañeda Heredia, P Puerta Roldan et al. Pediatric Blood & Cancer e26492
2017 Concomitant Use of Panobinostat and Reirradiation in Progressive DIPG: Report of 2 Cases ZJ Wang, Y Ge, D Altinok, J Poulik, S Sood, JW Taub et al. Journal of Pediatric Hematology/Oncology Epub ahead of print
2016 Pre-radiation chemotherapy improves survival in pediatric diffuse intrinsic pontine gliomas Gokce-Samar Z, Beuriat PA, Faure-Conter C, Carrie C, Chabaud S, Claude L, Di Rocco F, Mottolese C, Szathmari A, Chabert C, Frappaz D. Childs Nerv Syst. 32(8):1415-23
2016 Diffuse Intrinsic Pontine Glioma in Children: Document or Treat? Pierre-Aurélien B, Alexandru S, Federico DR, Justyna K, Carmine M, Didier F. World Neurosurg. 93:485
2016 Molecular Drug Imaging: 89Zr-bevacizumab PET in Children with Diffuse Intrinsic Pontine Glioma Jansen M, Veldhuijzen van Zanten SE, Van Vuurden DG, Huisman M, Vugts DJ, Hoekstra OS, van Dongen GA, Kaspers GJ. J Nucl Med. Epub ahead of print
2016 A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma El-Habr EA, Dubois LG, Burel-Vandenbos F, Bogeas A, Lipecka J, Turchi L, Lejeune FX, Coehlo PL, Yamaki T, Wittmann BM, Fareh M, Mahfoudhi E, Janin M, Narayanan A, Morvan-Dubois G, Schmitt C, Verreault M, Oliver L, Sharif A, Pallud J, Devaux B, Puget S, Korkolopoulou P, Varlet P, Ottolenghi C, Plo I, Moura-Neto V, Virolle T, Chneiweiss H, Junier MP. Acta Neuropathol. Epub ahead of print
2016 A phase I study of perifosine with temsirolimus for recurrent pediatric solid tumors Becher OJ, Gilheeney SW, Khakoo Y, Lyden DC, Haque S, De Braganca KC, Kolesar JM, Huse JT, Modak S, Wexler LH, Kramer K, Spasojevic I, Dunkel IJ. Pediatr Blood Cancer. Epub ahead of print
2017 Diffuse intrinsic pontine gliomas in children: Interest of robotic frameless assisted biopsy. A technical note. Coca HA, Cebula H, Benmekhbi M, Chenard MP, Entz-Werle N, Proust F. Neurochirurgie. 62(6):327-331
2017 Survival benefit for patients with diffuse intrinsic pontine glioma (DIPG) undergoing re-irradiation at first progression: A matched-cohort analysis on behalf of the SIOP-E-HGG/DIPG working group Janssens GO, Gandola L, Bolle S, Mandeville H, Ramos-Albiac M, van Beek K, Benghiat H, Hoeben B, La Madrid AM, Kortmann RD, Hargrave D, Menten J, Pecori E, Biassoni V, von Bueren AO, van Vuurden DG, Massimino M, Sturm D, Peters M, Kramm CM. Eur J Cancer. 73:38-47
2017 New in vivo avatars of diffuse intrinsic pontine gliomas (DIPG) from stereotactic biopsies performed at diagnosis Plessier A, Dret LL, Varlet P, Beccaria K, Lacombe J, Mériaux S, Geffroy F, Fiette L, Flamant P, Chrétien F, Blauwblomme T, Puget S, Grill J, Debily MA, Castel D. Oncotarget. Epub ahead of print
2017 Dual Inhibition of PI3K/AKT and MEK/ERK Pathways Induces Synergistic Antitumor Effects in Diffuse Intrinsic Pontine Glioma Cells Wu YL, Maachani UB, Schweitzer M, Singh R, Wang M, Chang R, Souweidane MM. Transl Oncol. 10(2):221-228
2017 The role of histone modifications and telomere alterations in the pathogenesis of diffuse gliomas in adults and children Julieann LeeDavid A. SolomonTarik Tihan Neurooncol. Online
2017 Rapid and fulminant leptomeningeal spread following radiotherapy in diffuse intrinsic pontine glioma Christopher L. Tinkle, Brent A. Orr, John T. Lucas Jr., Paul Klimo, Zoltan Patay, Suzanne J. Baker, Alberto Broniscer, Ibrahim Qaddoumi Pediatr Blood Cancer Online
2017 Biomarker based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models Susanne Kossatz, Brandon Carney, Melanie E. Schweitzer, Giuseppe Carlucci, Vesselin Miloushev, Uday B. Maachani, Prajwal Rajappa, Kayvan Keshari, David J. Pisapia, Wolfgang A. Weber, Mark M Souweidane and Thomas Reiner Cancer Research Online
2017 Development of a DIPG Orthotopic Model in Mice Using an Implantable Guide-Screw System Miguel Marigil , Naiara Martinez-Velez , Pablo D. Domínguez, Miguel Angel Idoate, Enric Xipell, Ana Patiño-García, Marisol Gonzalez-Huarriz, Marc García-Moure, Marie-Pierre Junier, Hervé Chneiweiss, Elías El-Habr, Ricardo Diez-Valle, Sonia Tejada-Solís, Marta M. Alonso PLOS One Online
2017 Neonatal Respiratory Failure Caused by Congenital Diffuse Intrinsic Pontine Glioma Katie M. Satrom, Rachel A. Phelan, Christopher L. Moertel, H. Brent Clark, Dana E. Johnson,Thomas N. George Journal of Child Neurology
2017 A phase II trial of radiation and cetuximab followed by irinotecan/cetuximab for children with newly diagnosed diffuse pontine tumors and high-grade astrocytomas Mark W. Kieran, Susan N. Chi, Kenneth J. Cohen, Tobey MacDonald, Amy A. Smith, Michael Matthew Etzl, Aru Narendran, Lia Gore... Jennifer DiRenzo, Tanya M. Trippett, Nicholas K. Foreman, Ira J. Dunkel Journal of Clinical Oncology 31, no. 15_suppl (May 2013) 10030-10030
2017 Convection-Enhanced Delivery for Diffuse Intrinsic Pontine Glioma Treatment Zhou Z, Singh R, Souweidane MM. Curr Neuropharmacol. 2017;15(1):116-128.
2017 Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease van Zanten, S.E.M.V., Baugh, J., Chaney, B. et al. J Neurooncol. First Online: 21 January 2017
2017 The international diffuse intrinsic pontine glioma registry: an infrastructure to accelerate collaborative research for an orphan disease Baugh, J., Bartels, U., Leach, J. et al. J Neurooncol. First Online: 16 January 2017
2017 Pre-Clinical Study of Panobinostat in Xenograft and Genetically Engineered Murine Diffuse Intrinsic Pontine Glioma Models. Tammy Hennika , Guo Hu , Nagore G. Olaciregui, Kelly L. Barton, Anahid Ehteda, Arjanna Chitranjan, Cecilia Chang, Andrew J. Gifford, Maria Tsoli, David S. Ziegler, Angel M. Carcaboso, Oren J. Becher PLoS One Jan 4 12(1):e 0169485
2017 Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies. Maury E, Hashizume R. Epigenetics Epub ahead of print
2016 Brainstem Glioma in Adults Jethro Hu, Stephen Western, and Santosh Kesari Front Oncol. 6: 180.
2016 Children with minimal chance for cure: parent proxy of the child’s health-related quality of life and the effect on parental physical and mental health during treatment. Mandrell BN, Baker J, Levine D, Gattuso J, West N, Sykes A, Gajjar A, Broniscer A. J Neurooncol. 129(2):373-81
2016 Discrepant longitudinal volumetric and metabolic evolution of diffuse intrinsic Pontine gliomas during treatment: implications for current response assessment strategies. Löbel U, Hwang S, Edwards A, Li Y, Li X, Broniscer A, Patay Z. Neuroradiology 58(10):1027-1034
2016 Bioinformatics analysis of the molecular mechanism of diffuse intrinsic pontine glioma. Deng L, Xiong P, Luo Y, Bu X, Qian S, Zhong W. Oncol Lett. 12(4):2524-2530
2016 Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma. Amani V, Prince EW, Alimova I, Balakrishnan I, Birks D, Donson AM, Harris P, Levy JM, Handler M, Foreman NK, Venkataraman S, Vibhakar R. BMC Cancer. 16:647
2016 A molecular biology and phase II study of imetelstat (GRN163L) in children with recurrent or refractory central nervous system malignancies: a pediatric brain tumor consortium study. Salloum R, Hummel TR, Kumar SS, Dorris K, Li S, Lin T, Daryani VM, Stewart CF, Miles L, Poussaint TY, Stevenson C, Goldman S, Dhall G, Packer R, Fisher P, Pollack IF, Fouladi M, Boyett J, Drissi R. J Neurooncol. 129(3):443-51
2016 Diffuse Intrinsic Pontine Glioma: Time for Cautious Optimism. Hennika T, Becher OJ. J Child Neurol. 31(12):1377-85
2016 Biopsy for diffuse intrinsic pontine glioma: a reappraisal. Kieran, Goumnerova, Prados, Gupta J Neurosurg Pediatr. 18(3):390-1
2016 Re-examining the need for tissue diagnosis in Pediatric Diffuse Intrinsic Pontine Gliomas: a review. Infinger LK, Stevenson CB. Curr Neuropharmacol. Epub ahead of print
2016 More support for clinical trials in children Nature Editorial Nature Nature 535, 465–466
2016 State of affairs in use of steroids in diffuse intrinsic pontine glioma: an international survey and a review of the literature. Veldhuijzen van Zanten SE, Cruz O, Kaspers GJ, Hargrave DR, van Vuurden DG; SIOPE DIPG Network. J Neurooncol. 128(3):387-94
2016 Talking to Children With Cancer: Sometimes Less Is More David N. Korones JCO Epub ahead of print
2016 Diffuse Intrinsic Pontine Glioma in children : document or treat ? Beuriat PA, Szathmari A, Di Rocco F, Kanold J, Mottolese C, Frappaz D World Neurosurg. Epub ahead of print
2016 A novel magnetic resonance imaging segmentation technique for determining diffuse intrinsic pontine glioma tumor volume. Singh R, Zhou Z, Tisnado J, Haque S, Peck KK, Young RJ, Tsiouris AJ, Thakur SB, Souweidane MM. J Neurosurg Pediatr. Epub ahead of print
2016 Pre-radiation chemotherapy improves survival in pediatric diffuse intrinsic pontine gliomas. Gokce-Samar Z, Beuriat PA, Faure-Conter C, Carrie C, Chabaud S, Claude L, Di Rocco F, Mottolese C, Szathmari A, Chabert C, Frappaz D. Childs Nerv Syst. Epub ahead of print
2016 Histological and molecular analysis of a progressive diffuse intrinsic pontine glioma and synchronous metastatic lesions: a case report. Nazarian J, Mason GE, Ho CY, Panditharatna E, Kambhampati M, Vezina LG, Packer RJ, Hwang EI. Oncotarget. Epub ahead of print
2016 Bevacizumab targeting diffuse intrinsic pontine glioma: results of 89Zr-bevacizumab PET imaging in brain tumor models. Jansen MH, Lagerweij T, Sewing AC, Vugts DJ, van Vuurden DG, Molthoff CF, Caretti V, Veringa SJ, Petersen N, Montero-Carcaboso A, Noske DP, Vandertop WP, Wesseling P, van Dongen GA, Kaspers GJ, Hulleman E. Mol Cancer Ther. Epub ahead of print
2016 Pediatric high-grade glioma: biologically and clinically in need of new thinking. Jones C, Karajannis MA, Jones DT, Kieran MW, Monje M, Baker SJ, Becher OJ, Cho YJ, Gupta N, Hawkins C, Hargrave D, Haas-Kogan DA, Jabado N, Li XN, Mueller S, Nicolaides T, Packer RJ, Persson AI, Phillips JJ, Simonds EF, Stafford JM, Tang Y, Pfister SM, Weiss WA. Neuro Oncol. Epub ahead of print
2016 In silico analysis of histone H3 gene expression during humanbrain development. Ren M, van Nocker S. Int J Dev Biol. Epub ahead of print
2016 Pediatric and Adult High-Grade Glioma Stem Cell Culture Models Are Permissive to Lytic Infection with Parvovirus H-1. Josupeit R, Bender S, Kern S, Leuchs B, Hielscher T, Herold-Mende C, Schlehofer JR, Dinsart C, Witt O, Rommelaere J, Lacroix J. Viruses 19;8(5)
2016 Pseudoprogression in children, adolescents and young adults with non-brainstem high grade glioma and diffuse intrinsic pontine glioma. Carceller F, Fowkes LA, Khabra K, Moreno L, Saran F, Burford A, Mackay A, Jones DT, Hovestadt V, Marshall LV, Vaidya S, Mandeville H, Jerome N, Bridges LR, Laxton R, Al-Sarraj S, Pfister SM, Leach MO, Pearson AD, Jones C, Koh DM, Zacharoulis S. J Neurooncol. Epub ahead of print
2016 Investigational new drugs for brain cancer. Staedtke V, Bai RY, Laterra J. Expert Opin Investig Drugs. Epub ahead of print
2016 Diffuse Intrinsic Pontine Glioma: New Pathophysiological Insights and Emerging Therapeutic Targets. Johung TB, Monje M. Curr Neuropharmacol Epub ahead of print
2016 No Significant Cytotoxic Effect of the EZH2 Inhibitor Tazemetostat (EPZ-6438) on Pediatric Glioma Cells with Wildtype Histone 3 or Mutated Histone 3.3. Wiese M, Schill F, Sturm D, Pfister S, Hulleman E, Johnsen SA, Kramm CM Klin Padiatr. 228(3):113-117
2016 Conventional and Advanced Imaging of Diffuse Intrinsic Pontine Glioma. Tisnado J, Young R, Peck KK, Haque S. J Child Neurol. Epub ahead of print
2016 Histone H3 genotyping refines clinico-radiological diagnostic and prognostic criteria in DIPG. Castel D, Grill J, Debily MA. Acta Neuropathol. 131(5):795-6.
2016 Pediatric gliomas as neurodevelopmental disorders. Baker SJ, Ellison DW, Gutmann DH. Glia. 2016 64(6):879-95
2016 Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma. Nikbakht H, Panditharatna E, Mikael LG, Li R, Gayden T, Osmond M, Ho CY, Kambhampati M, Hwang EI, Faury D, Siu A, Papillon-Cavanagh S, Bechet D, Ligon KL, Ellezam B, Ingram WJ, Stinson C, Moore AS, Warren KE, Karamchandani J, Packer RJ, Jabado N, Majewski J, Nazarian J. Nat Commun. 7:11185.
2016 Palliative and end-of-life care for children with diffuse intrinsic pontine glioma: results from a London cohort study and international survey. Veldhuijzen van Zanten SE, van Meerwijk CL, Jansen MH, Twisk JW, Anderson AK, Coombes L, Breen M, Hargrave OJ, Hemsley J, Craig F, Cruz O, Kaspers GJ, van Vuurden DG, Hargrave DR; SIOPE DIPG Network. Neuro Oncol. 2016 Apr;18(4):582-8.
2016 Local delivery methods of therapeutic agents in the treatment of diffuse intrinsic brainstem gliomas. Goodwin CR, Xu R, Iyer R, Sankey EW, Liu A, Abu-Bonsrah N, Sarabia-Estrada R, Frazier JL, Sciubba DM, Jallo GI. Clin Neurol Neurosurg. 2016 Mar;142:120-7.
2016 A pilot study of bevacizumab-based therapy in patients with newly diagnosed high-grade gliomas and diffuse intrinsic pontine gliomas. Hummel TR, Salloum R, Drissi R, Kumar S, Sobo M, Goldman S, Pai A, Leach J, Lane A, Pruitt D, Sutton M, Chow LM, Grimme L, Doughman R, Backus L, Miles L, Stevenson C, Fouladi M, DeWire M. J Neurooncol. 2016 Mar;127(1):53-61
2016 Nanotechnology Applications for Diffuse Intrinsic Pontine Glioma. Bredlau AL, Dixit S, Chen C, Broome AM. Curr Neuropharmacol. Epub ahead of print
2016 Common mutations in ALK2/ACVR1, a multi-faceted receptor, have roles in distinct pediatric musculoskeletal and neural orphan disorders. Pacifici M, Shore EM. Cytokine Growth Factor Rev. 2016 Feb;27:93-104
2016 Chronic, intermittent convection-enhanced delivery devices. Lewis O, Woolley M, Johnson D, Rosser A, Barua NU, Bienemann AS, Gill SS, Evans S. J Neurosci Methods. 259:47-56.
2016 Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics. Hoffman LM, DeWire M, Ryall S, Buczkowicz P, Leach J, Miles L, Ramani A, Brudno M, Kumar SS, Drissi R, Dexheimer P, Salloum R, Chow L, Hummel T, Stevenson C, Lu QR, Jones B, Witte D, Aronow B, Hawkins CE, Fouladi M. Acta Neuropathol Commun. 4;4(1):1.
2016 Tumor location, but not H3.3K27M, significantly influences the blood-brain-barrier permeability in a genetic mouse model of pediatric high-grade glioma. Subashi E, Cordero FJ, Halvorson KG, Qi Y, Nouls JC, Becher OJ, Allan Johnson G. J Neurooncol. 126(2):243-51
2016 Detecting the H3F3A mutant allele found in high-grade pediatric glioma by real-time PCR. Zhang R, Han J, Daniels D, Huang H, Zhang Z J Neurooncol. 126(1):27-36
2016 Malignant brainstem tumors in children, excluding diffuse intrinsic pontine gliomas. Klimo P Jr, Nesvick CL, Broniscer A, Orr BA, Choudhri AF. J Neurosurg Pediatr. 17(1):57-65
2016 A Novel Mouse Model of Diffuse Intrinsic Pontine Glioma Initiated in Pax3-Expressing Cells. Misuraca KL, Hu G, Barton KL, Chung A, Becher OJ. Neoplasia. 18(1):60-70
2015 Common mutations in ALK2/ACVR1, a multi-faceted receptor, have roles in distinct pediatric musculoskeletal and neural orphan disorders. Pacifici M, Shore EM. Cytokine Growth Factor Rev Epub ahead of print
2015 Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes. Castel D, Philippe C, Calmon R, Le Dret L, Truffaux N, Boddaert N, Pagès M, Taylor KR, Saulnier P, Lacroix L, Mackay A, Jones C, Sainte-Rose C, Blauwblomme T, Andreiuolo F, Puget S, Grill J, Varlet P, Debily MA. Acta Neuropathol. 30(6):815-27
2015 Pediatric brainstem abscess with hemorrhage mimicking diffuse intrinsic pontine glioma: a case report. Kim JH, Jung TY, Jung SH, Lee KH, Kim SK. Childs Nerv Syst. 31(12):2359-62
2015 A pilot study of bevacizumab-based therapy in patients with newly diagnosed high-grade gliomas and diffuse intrinsic pontine gliomas. Hummel TR, Salloum R, Drissi R, Kumar S, Sobo M, Goldman S, Pai A, Leach J, Lane A, Pruitt D, Sutton M, Chow LM, Grimme L, Doughman R, Backus L, Miles L, Stevenson C, Fouladi M, DeWire M. J Neurooncol. Epub ahead of print
2015 Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma. Chornenkyy Y, Agnihotri S, Yu M, Buczkowicz P, Rakopoulos P, Golbourn B, Garzia L, Siddaway R, Leung S, Rutka JT, Taylor MD, Dirks PB, Hawkins C. Mol Cancer Ther. 14(11):2560-8
2015 Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations. Solomon DA, Wood MD, Tihan T, Bollen AW, Gupta N, Phillips JJ, Perry A. Brain Pathol. Epub ahead of print
2015 Apparent diffusion coefficient histogram metrics correlate with survival in diffuse intrinsic pontine glioma: a report from the Pediatric Brain Tumor Consortium. Poussaint TY, Vajapeyam S, Ricci KI, Panigrahy A, Kocak M, Kun LE, Boyett JM, Pollack IF, Fouladi M. Neuro Oncol. Epub ahead of print
2015 Palliative and end-of-life care for children with diffuse intrinsic pontine glioma: results from a London cohort study and international survey. Veldhuijzen van Zanten SE, van Meerwijk CL, Jansen MH, Twisk JW, Anderson AK, Coombes L, Breen M, Hargrave OJ, Hemsley J, Craig F, Cruz O, Kaspers GJ, van Vuurden DG, Hargrave DR; SIOPE DIPG Network. Neuro Oncol. Epub ahead of print
2015 Biopsy in a series of 130 pediatric diffuse intrinsic Pontine gliomas. Puget S, Beccaria K, Blauwblomme T, Roujeau T, James S, Grill J, Zerah M, Varlet P, Sainte-Rose C. Childs Nerv Syst. 31(10):1773-80
2015 P-glycoprotein and breast cancer resistance protein restrict the brain penetration of the CDK4/6 inhibitor palbociclib. de Gooijer MC, Zhang P, Thota N, Mayayo-Peralta I, Buil LC, Beijnen JH, van Tellingen O. Invest New Drugs. 33(5):1012-9
2015 Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition. Taylor IC, Hütt-Cabezas M, Brandt WD, Kambhampati M, Nazarian J, Chang HT, Warren KE, Eberhart CG, Raabe EH. J Neuropathol Exp Neurol. 74(8):778-90.
2015 Managing teenage/young adult (TYA) brain tumors: a UK perspective. Alken SP, D'Urso P, Saran FH. CNS Oncol. 4(4):235-46
2015 Pediatric brainstem abscess with hemorrhage mimicking diffuse intrinsic pontine glioma: a case report. Kim JH, Jung TY, Jung SH, Lee KH, Kim SK Childs Nerv Syst. Epub ahead of print
2015 Pathology, Molecular Genetics, and Epigenetics of Diffuse Intrinsic Pontine Glioma. Buczkowicz P, Hawkins C. Front Oncol. eCollection
2015 140 A High-Throughput In Vitro Drug Screen in a Genetically Engineered Mouse Model of Diffuse Intrinsic Pontine Glioma Identifies BMS-754807 as a Promising Therapeutic Agent. Halvorson KG, Barton KL, Schroeder K, Misuraca K, Hoeman C, Chung A, Crabtree D, Cordero F, Singh R, Spasojevic I, Berlow N, Pal R, Becher O. Neurosurgery 62 Suppl 1:211
2015 Future Clinical Trials in DIPG: Bringing Epigenetics to the Clinic. Morales La Madrid A, Hashizume R, Kieran MW. Front Oncol. eCollection
2015 Clinicopathology of diffuse intrinsic pontine glioma and its redefined genomic and epigenomic landscape. Panditharatna E, Yaeger K, Kilburn LB, Packer RJ, Nazarian J. Cancer Genet. 208(7-8):367-73
2015 Pre-Clinical Models of Diffuse Intrinsic Pontine Glioma. Misuraca KL, Cordero FJ, Becher OJ. Front Oncol.  eCollection
2015 Preclinical evaluation of dasatinib alone and in combination with cabozantinib for the treatment of diffuse intrinsic pontine glioma. Truffaux N, Philippe C, Paulsson J, Andreiuolo F, Guerrini-Rousseau L, Cornilleau G, Le Dret L, Richon C, Lacroix L, Puget S, Geoerger B, Vassal G, Östman A, Grill J. Neuro Oncol. 17(7):953-64
2015 Incidental diagnosis of diffuse intrinsic pontine glioma in children. Wright KD, Sabin ND, Cheuk D, McNall-Knapp R, Shurtleff SA, Gajjar A, Broniscer A. Pediatr Blood Cancer. 62(6):1081-3
2015 Incidental diagnosis of diffuse intrinsic pontine glioma in children. Wright KD, Sabin ND, Cheuk D, McNall-Knapp R, Shurtleff SA, Gajjar A, Broniscer A. Pediatr Blood Cancer. 62(6):1081-3
2015 The emerging role of NG2 in pediatric diffuse intrinsic pontine glioma Yadavilli S, Scafidi J, Becher OJ, Saratsis AM, Hiner RL, Kambhampati M, Mariarita S, MacDonald TJ, Codispoti KE, Magge SN, Jaiswal JK, Packer RJ, Nazarian J. Oncotarget. 20;6(14):12141-55.
2015 A standardized autopsy procurement allows for the comprehensive study of DIPG biology. Kambhampati M, Perez JP, Yadavilli S, Saratsis AM, Hill AD, Ho CY, Panditharatna E, Markel M, Packer RJ, Nazarian J. Oncotarget. 20;6(14):12740-7
2015 Accuracy of direct magnetic resonance imaging-guided placement of drug infusion cannulae. Chittiboina P, Heiss JD, Lonser RR. J Neurosurg. 122(5):1173-9
2015 Toxicity evaluation of convection-enhanced delivery of small-molecule kinase inhibitors in naïve mouse brainstem. Zhou Z, Ho SL, Singh R, Pisapia DJ, Souweidane MM. Childs Nerv Syst. 31(4):557-62
2015 Citrate concentrations increase with hypoperfusion in pediatric diffuse intrinsic pontine glioma. Yeom KW, Lober RM, Nelson MD Jr, Panigrahy A, Blüml S. J Neurooncol. 122(2):383-9
2015 Pediatric brainstem gliomas: new understanding leads to potential new treatments for two very different tumors. Green AL, Kieran MW. Curr Oncol Rep. 17(3):436
2015 Cell migration in paediatric glioma; characterisation and potential therapeutic targeting. Cockle JV, Picton S, Levesley J, Ilett E, Carcaboso AM, Short S, Steel LP, Melcher A, Lawler SE, Brüning-Richardson A. Br J Cancer. 112(4):693-703
2015 A twenty-year review of diagnosing and treating children with diffuse intrinsic pontine glioma in The Netherlands. Veldhuijzen van Zanten SE, Jansen MH, Sanchez Aliaga E, van Vuurden DG, Vandertop WP, Kaspers GJ. Expert Rev Anticancer Ther. 15(2):157-64
2015 Temozolomide in the treatment of newly diagnosed diffuse brainstem glioma in children: a broken promise? Rizzo D, Scalzone M, Ruggiero A, Maurizi P, Attinà G, Mastrangelo S, Lazzareschi I, Ridola V, Colosimo C, Caldarelli M, Balducci M, Riccardi R. J Chemother. 27(2):106-10.
2015 Patterns of progression in pediatric patients with high-grade glioma or diffuse intrinsic pontine glioma treated with Bevacizumab-based therapy at diagnosis. Salloum R, DeWire M, Lane A, Goldman S, Hummel T, Chow L, Miles L, Sutton M, Stevenson C, Fouladi M, Leach J. J Neurooncol. 121(3):591-8
2015 Diffuse intrinsic pontine glioma: is MRI surveillance improved by region of interest volumetry? Riley GT, Armitage PA, Batty R, Griffiths PD, Lee V, McMullan J, Connolly DJ. Pediatr Radiol. 45(2):203-10
2015 Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria. Jansen MH, Veldhuijzen van Zanten SE, Sanchez Aliaga E, Heymans MW, Warmuth-Metz M, Hargrave D, van der Hoeven EJ, Gidding CE, de Bont ES, Eshghi OS, Reddingius R, Peeters CM, Schouten-van Meeteren AY, Gooskens RH, Granzen B, Paardekooper GM, Janssens GO, Noske DP, Barkhof F, Kramm CM, Vandertop WP, Kaspers GJ, van Vuurden DG. Neuro Oncol. 17(1):160-6
2015 Profile of nimotuzumab in the treatment of high-grade glioma. Yang QY, Guo CC, Chen ZP. Onco Targets Ther. 13;8:819-25
2015 A high-throughput in vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent. Halvorson KG, Barton KL, Schroeder K, Misuraca KL, Hoeman C, Chung A, Crabtree DM, Cordero FJ, Singh R, Spasojevic I, Berlow N, Pal R, Becher OJ. PLoS One. 10(3):e0118926
2014 Histopathological spectrum of paediatric diffuse intrinsic pontine glioma: diagnostic and therapeutic implications. Buczkowicz P, Bartels U, Bouffet E, Becher O, Hawkins C. Acta Neuropathol.  128(4):573-81.
2014 Measuring the pons: a non-invasive biomarker for pediatric diffuse intrinsic pontine glioma. Warren KE. CNS Oncol.  3(3):181-3. 
2014 Structure-Activity Relationship of 3,5-Diaryl-2-aminopyridine ALK2 Inhibitors Reveals Unaltered Binding Affinity for Fibrodysplasia Ossificans Progressiva Causing Mutants. Mohedas AH, Wang Y, Sanvitale CE, Canning P, Choi S, Xing X, Bullock AN, Cuny GD, Yu PB. J Med Chem. 57(19):7900-15
2014 ACVR1 mutations in DIPG: lessons learned from FOP. Taylor KR, Vinci M, Bullock AN, Jones C Cancer Res. 74(17):4565-70.
2014 Molecular genetics of ependymomas and pediatric diffuse gliomas: a short review. Nobusawa S, Hirato J, Yokoo H. Brain Tumor Pathol. 31(4):229-33
2014 The genetic signatures of pediatric high-grade glioma: no longer a one-act play. Diaz AK, Baker SJ. Semin Radiat Oncol. 24(4):240-7
2014 Clinicopathological features and treatment outcomes of brain stem gliomas in Saudi population Bayoumi Y, Sabbagh AJ, Mohamed R, ElShokhaiby UM, Maklad AM, Tunio MA, Balbaid AA. World J Clin Oncol. 10;5(5):1060-7.
2014 Commentary on: “The response and survival of children with recurrent diffuse intrinsic pontine glioma based on phase II study of antineoplastons A10 and AS2-1 in patients with brainstem glioma.” By Burzynski et al. Perilongo G. Childs Nerv Syst. 30(12):2071-2.
2014 Primary brain tumors and posterior reversible encephalopathy syndrome. Bayoumi Y, Sabbagh AJ, Mohamed R, ElShokhaiby UM, Maklad AM, Tunio MA, Balbaid AA. Neurooncol Pract. 1(4):184-190
2014 Randomized trial on radiotherapy for paediatric diffuse intrinsic pontine glioma (DIPG). Roos DE, Smith JG. Radiother Oncol. 113(3):425
2014 Management of diffuse intrinsic pontine glioma in children: current and future strategies for improving prognosis Kaye EC, Baker JN, Broniscer A. CNS Oncol. 3(6):421-31
2014 The genetic signatures of pediatric high-grade glioma: no longer a one act play. Diaz AK, Baker SJ. Semin Radiat Oncol. 24(4):240-7
2014 Diffuse intrinsic pontine glioma biopsy: A single institution experience. Wang ZJ, Rao L, Bhambhani K, Miller K, Poulik J, Altinok D, Sood S Pediatr Blood Cancer. online ahead of print
2014 Can Multiparametric MRI and FDG-PET Predict Outcome in Diffuse Brainstem Glioma? A Report from a Prospective Phase-II Study. Goda JS, Dutta D, Raut N, Juvekar SL, Purandare N, Rangarajan V, Arora B, Gupta T, Kurkure P, Jalali R. Pediatr Neurosurg. online ahead of print
2014 Convection enhanced delivery of carmustine to the murine brainstem: A feasibility study. Sewing AC, Caretti V, Lagerweij T, Schellen P, Jansen MH, van Vuurden DG, Idema S, Molthoff CF, Vandertop WP, Kaspers GJ, Noske DP, Hulleman E. J Neurosci Methods online ahead of print
2014 Time to rethink the unthinkable: Upfront biopsy of children with newly diagnosed diffuse intrinsic pontine glioma (DIPG). Kieran MW. Pediatr Blood Cancer online ahead of print
2014 Pax3 expression enhances PDGF-B-induced brainstem gliomagenesis and characterizes a subset of brainstem glioma. Misuraca KL, Barton KL, Chung A, Diaz AK, Conway SJ, Corcoran DL, Baker SJ, Becher OJ Acta Neuropathol Commun. 2(1):134
2014 Diffuse intrinsic pontine glioma: time for therapeutic optimism. Khatua S, Zaky W CNS Oncol. 3(5):337-48
2014 Aquaporin-4 autoimmunity masquerading as a brainstem tumor. Lim BC, Chae JH, Kim SK, Park SH, Wang KC, Lee JY, Phi JH J Neurosurg Pediatr online ahead of print
2014 Diffusion tensor histogram analysis of pediatric diffuse intrinsic pontine glioma. Steffen-Smith EA, Sarlls JE, Pierpaoli C, Shih JH, Bent RS, Walker L, Warren KE Biomed Res Int 2014, 647346, 9
2014 Subventricular spread of diffuse intrinsic pontine glioma Caretti V, Bugiani M, Freret M, Schellen P, Jansen M, van Vuurden D, Kaspers G, Fisher PG, Hulleman E, Wesseling P, Vogel H, Monje M Acta Neuropathol online ahead of print
2014 Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas. Zhang L1, Chen LH2, Wan H3, Yang R2, Wang Z4, Feng J5, Yang S6, Jones S7, Wang S8, Zhou W4, Zhu H4, Killela PJ4, Zhang J9, Wu Z9, Li G5, Hao S9, Wang Y9, Webb JB4, Friedman HS4, Friedman AH4, McLendon RE4, He Y4, Reitman ZJ4, Bigner DD4, Yan H Nat Genet. online ahead of print
2014 “Occult” post-contrast signal enhancement in pediatric diffuse intrinsic pontine glioma is the MRI marker of angiogenesis? Conway AE, Reddick WE, Li Y, Yuan Y, Glass JO, Baker JN, Kun LE, Broniscer A, Patay Z. Neuroradiology 56, 5, 405-412
2014 Results of nimotuzumab and vinorelbine, radiation and re-irradiation for diffuse pontine glioma in childhood. Massimino M1, Biassoni V, Miceli R, Schiavello E, Warmuth-Metz M, Modena P, Casanova M, Pecori E, Giangaspero F, Antonelli M, Buttarelli FR, Potepan P, Pollo B, Nunziata R, Spreafico F, Podda M, Anichini A, Clerici CA, Sardi I, De Cecco L, Bode U, Bach F, Gandola L J Neurooncol 18, 2, 305-312
2014 Human pontine glioma cells can induce murine tumors. Caretti V, Sewing AC, Lagerweij T, Schellen P, Bugiani M, Jansen MH, van Vuurden DG, Navis AC, Horsman I, Vandertop WP, Noske DP, Wesseling P, Kaspers GJ, Nazarian J, Vogel H, Hulleman E, Monje M, Wurdinger T Acta Neuropathol 127, 6, 897-909
2014 Diffuse intrinsic pontine glioma: a reassessment Robison NJ, Kieran MW J Neurooncol online ahead of print
2014 Phase 2 study of safety and efficacy of nimotuzumab in pediatric patients with progressive diffuse intrinsic pontine glioma. Bartels U, Wolff J, Gore L, Dunkel I, Gilheeney S, Allen J, Goldman S, Yalon M, Packer RJ, Korones DN, Smith A, Cohen K, Kuttesch J, Strother D, Baruchel S, Gammon J, Kowalski M, Bouffet E. Neuro Oncol online ahead of print
2014 Diffuse intrinsic pontine gliomas: treatments and controversies. Bredlau AL, Korones DN Adv Cancer Res 121, 235, 59
2014 Increased 5-hydroxymethylcytosine and decreased 5-methylcytosine are indicators of global epigenetic dysregulation in diffuse intrinsic pontine glioma Ahsan S, Raabe EH, Haffner MC, Vaghasia A, Warren KE, Quezado M, Ballester LY, Nazarian J, Eberhart CG, Rodriguez FJ Acta Neuropathol Commun 2, 59, 2051-5960
2014 Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological critrea Jansen MH, Veldhuijzen van Zanten Aliaga E, Heymas MW, Warmuth-Metz M, Hargrave D, van der Hoeven EJ, Gidding CE, de Bont ES, Eshghi OS, Reddingius R, Peeters CM, Schouten-van Meeteren AY, Gookens RH, Granzen B, Paardekooper GM, Kanssens GO, Noske DP, Barkhof F, Kramm CM, Vandertop WP, Kaspers GJ, van Vuurden DG Neuro Oncol. online ahead of print
2014 The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project. Nat Genet. online ahead of print
2014 Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma. Taylor KR, Mackay A, Truffaux N, Butterfield YS, Morozova O, Philippe C, Castel D, Grasso CS, Vinci M, Carvalho D, Carcaboso AM, de Torres C, Cruz O, Mora J, Entz-Werle N, Ingram WJ, Monje M, Hargrave D, Bullock AN, Puget S, Yip S, Jones C, Grill J. Nat Genet. 46, 5, 457-461
2014 Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations. Buczkowicz P, Hoeman C, Rakopoulos P, Pajovic S, Letourneau L, Dzamba M, Morrison A, Lewis P, Bouffet E, Bartels U, Zuccaro J, Agnihotri S, Ryall S, Barszczyk M, Chornenkyy Y, Bourgey M, Bourque G, Montpetit A, Cordero F, Castelo-Branco P, Mangerel J, Tabori U, Ho KC, Huang A, Taylor KR, Mackay A, Bendel AE, Nazarian J, Fangusaro JR, Karajannis MA, Zagzag D, Foreman NK, Donson A, Hegert JV, Smith A, Chan J, Lafay-Cousin L, Dunn S, Hukin J, Dunham C, Scheinemann K, Michaud J, Zelcer S, Ramsay D, Cain J, Brennan C, Souweidane MM, Jones C, Allis CD, Brudno M, Becher O, Hawkins C. Nat Genet. 46, 5, 451-456
2014 The response and survival of children with recurrent diffuse intrinsic pontine glioma based on phase II study of antineoplastons A10 and AS2-1 in patients with brainstem glioma. Burzynski SR, Janicki TJ, Burzynski GS, Marszalek A. Childs Nerv Syst. online ahead of print
2014 18?F-FDG PET standard uptake values of the normal pons in children: establishing a reference value for diffuse intrinsic pontine glioma. Jansen MH, Kloet RW, van Vuurden DG, van Zanten SE, Witte BI, Goldman S, Vandertop WP, Comans EF, Hoekstra OS, Boellaard R, Kaspers GJ. EJNMMI Res. 4(1):8
2014 Pediatric diffuse intrinsic pontine glioma patients from a single center. Kebudi R, Cakir FB, Agaoglu FY, Gorgun O, Ayan I, Darendeliler E. Childs Nerv Syst. (4):583-8.
2014 Morphologic characteristics and immunohistochemical profile of diffuse intrinsic pontine gliomas. Ballester LY, Wang Z, Shandilya S, Miettinen M, Burger PC, Eberhart CG, Rodriguez FJ, Raabe E, Nazarian J, Warren K, Quezado MM. Am J Surg Pathol. (9):1357-64.
2014 The potential of theragnostic 124I-8H9 convection-enhanced delivery in diffuse intrinsic pontine glioma. Luther N1, Zhou Z, Zanzonico P, Cheung NK, Humm J, Edgar MA, Souweidane MM. Neuro Oncol. online ahead of print
2014 Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy–results of a United Kingdom phase II trial (CNS 2007 04). Bailey S, Howman A, Wheatley K, Wherton D, Boota N, Pizer B, Fisher D, Kearns P, Picton S, Saran F, Gibson M, Glaser A, Connolly DJ, Hargrave D. Eur J Cancer. 49(18):3856-62
2014 Implementation of a multi-institutional diffuse intrinsic pontine glioma autopsy protocol and characterization of a primary cell culture. Caretti V, Jansen MH, van Vuurden DG, Lagerweij T, Bugiani M, Horsman I, Wessels H, van der Valk P, Cloos J, Noske DP, Vandertop WP, Wesseling P, Wurdinger T, Hulleman E, Kaspers GJ. Neuropathol Appl Neurobiol. 39(4):426-36
2014 Management of diffuse pontine gliomas in children: recent developments. Kebudi R, Cakir FB. Paediatr Drugs 15(5):351-62
2014 In vitro drug response and efflux transporters associated with drug resistance in pediatric high grade glioma and diffuse intrinsic pontine glioma. Veringa SJ, Biesmans D, van Vuurden DG, Jansen MH, Wedekind LE, Horsman I, Wesseling P, Vandertop WP, Noske DP, Kaspers GJ, Hulleman E PLoS One 8(4):e61512
2014 Aurora kinase B is a potential therapeutic’ target in pediatric diffuse intrinsic pontine glioma. Buczkowicz P, Zarghooni M, Bartels U, Morrison A, Misuraca KL, Chan T, Bouffet E, Huang A, Becher O, Hawkins C. Brain Pathol. 23(3):244-53
2014 Hypofractionated conformal radiotherapy for pediatric diffuse intrinsic pontine glioma (DIPG): A randomized controlled trial. Zaghloul MS, Eldebawy E, Ahmed S, Mousa AG, Amin A, Refaat A, Zaky I, Elkhateeb N, Sabry M. Radiother Oncol. online ahead of print
2014 A multi-disciplinary consensus statement concerning surgical approaches to low-grade, high-grade astrocytomas and diffuse intrinsic pontine gliomas in childhood (CPN Paris 2011) using the Delphi method. Walker DA, Liu J, Kieran M, Jabado N, Picton S, Packer R, St Rose C; CPN Paris 2011 Conference Consensus Group. Neuro Oncol. 15(4):462-8
2014 Phase I trial, pharmacokinetics, and pharmacodynamics of vandetanib and dasatinib in children with newly diagnosed diffuse intrinsic pontine glioma. Broniscer A, Baker SD, Wetmore C, Pai Panandiker AS, Huang J, Davidoff AM, Onar-Thomas A, Panetta JC, Chin TK, Merchant TE, Baker JN, Kaste SC, Gajjar A, Stewart CF Clin Cancer Res. 1;19(11):3050-8
2014 Craniospinal irradiation with concurrent temozolomide and nimotuzumab in a child with primary metastatic diffuse intrinsic pontine glioma. A compassionate use treatment. Müller K, Schlamann A, Seidel C, Warmuth-Metz M, Christiansen H, Vordermark D, Kortmann RD, Kramm CM, von Bueren AO. Strahlenther Onkol. 189(8):693-6
2014 Effect of time from diagnosis to start of radiotherapy on children with diffuse intrinsic pontine glioma. Pai Panandiker AS, Wong JK, Nedelka MA, Wu S, Gajjar A, Broniscer A. Pediatr Blood Cancer 61, 7, 1180-1183
2014 Magnetic resonance imaging properties of convective delivery in diffuse intrinsic pontine gliomas. Chittiboina P, Heiss JD, Warren KE, Lonser RR. J Neurosurg Pediatr. 13(3):276-82
2014 Children are not just little adults: recent advances in understanding of diffuse intrinsic pontine glioma biology. Schroeder KM, Hoeman CM, Becher OJ. Pediatr Res. 75(1-2):205-9
2014 Diffusion-weighted MRI derived apparent diffusion coefficient identifies prognostically distinct subgroups of pediatric diffuse intrinsic pontine glioma. Lober RM, Cho YJ, Tang Y, Barnes PD, Edwards MS, Vogel H, Fisher PG, Monje M, Yeom KW. J Neurooncol. 117(1):175-82
2014 MR imaging assessment of tumor perfusion and 3D segmented volume at baseline, during treatment, and at tumor progression in children with newly diagnosed diffuse intrinsic pontine glioma. Sedlacik J, Winchell A, Kocak M, Loeffler RB, Broniscer A, Hillenbrand CM. AJNR Am J Neuroradiol 34(7):1450-5
2014 Superselective Intracerebral Catheterization for Administration of Oncolytic Virotherapy in a Case of Diffuse Intrinsic Pontine Glioma. Carceller F, Aleu A, Casasco A, Guimaraens L, López-Pino MA, Madero L, Ramírez M. J Pediatr Hematol Oncol. online ahead of print
2014 Comparative multidimensional molecular analyses of pediatric diffuse intrinsic pontine glioma reveals distinct molecular subtypes. Saratsis AM, Kambhampati M, Snyder K, Yadavilli S, Devaney JM, Harmon B, Hall J, Raabe EH, An P, Weingart M, Rood BR, Magge SN, Macdonald TJ, Packer RJ, Nazarian J. Acta Neuropathol. 127, 6, 881-895
2014 Treatment of children with diffuse intrinsic pontine gliomas with chemoradiotherapy followed by a combination of temozolomide, irinotecan, and bevacizumab. Zaky W, Wellner M, Brown RJ, Blüml S, Finlay JL, Dhall G. Pediatr Hematol Oncol. 30(7):623-32
2014 Retrospective evaluation of the outcomes of children with diffuse intrinsic pontine glioma treated with radiochemotherapy and valproic acid in a single center. Felix FH, de Araujo OL, da Trindade KM, Trompieri NM, Fontenele JB. J Neurooncol. 116(2):261-6
2014 Diffuse intrinsic pontine glioma in children and adolescents: a single-center experience. Vallero SG, Bertin D, Basso ME, Pittana LS, Mussano A, Fagioli F. Childs Nerv Syst. 30, 6, 1061-1066
2014 Clinico-radiologic characteristics of long-term survivors of diffuse intrinsic pontine glioma. Jackson S, Patay Z, Howarth R, Pai Panandiker AS, Onar-Thomas A, Gajjar A, Broniscer A. J Neurooncol. 114(3):339-44
2014 The efficacy of a biopsy of intrinsic brainstem lesions for decision making of the treatments. Ogiwara H, Morota N. Childs Nerv Syst. 29(5):833-7
2014 Editorial: Convection-enhanced delivery for diffuse intrinsic pontine glioma. Souweidane MM. J Neurosurg Pediatr. 13(3):273-5
2014 A diffuse intrinsic pontine glioma roadmap: Guiding research toward a cure. Smith SE, Waller JC, Bingham IA, Jewett DM, Nsouli MS, Mackintosh JJ. Pediatr Blood Cancer. abstract unavailable
2014 A diffuse intrinsic pontine glioma in a neonate diagnosed by MRI. Gabel BC, Yoon J, Levy ML, Crawford JR. BMJ Case Rep. abstract unavailable
2014 Preliminary experience with diffusion tensor imaging before and after re-irradiation treatments in children with progressive diffuse pontine glioma. Khatua S, Hou P, Bodiwala R, Wolff J, Hamilton J, Patil S, Zaky W, Mahajan A, Ketonen L. Childs Nerv Syst. 30, 5, 925-930
2013 Brainstem glioma: a review. Grimm SA, Chamberlain MC. Curr Neurol Neurosci Rep. 13(5):346
2013 Convection-enhanced delivery of topotecan into diffuse intrinsic brainstem tumors in children. Anderson RC, Kennedy B, Yanes CL, Garvin J, Needle M, Canoll P, Feldstein NA, Bruce JN. J Neurosurg Pediatr 11(3):289-95.
2013 Targeting Wee1 for the treatment of pediatric high-grade gliomas. Mueller S, Hashizume R, Yang X, Kolkowitz I, Olow AK, Phillips J, Smirnov I, Tom MW, Prados MD, James CD, Berger MS, Gupta N, Haas-Kogan DA. Neuro Oncol. 16(3):352-60
2013 Measurements of the pons as a biomarker of progression for pediatric DIPG. Steffen-Smith EA, Baker EH, Venzon D, Shandilya S, Bent RS, Warren KE. J Neurooncol. 116(1):127-33
2013 Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children. Cage TA, Samagh SP, Mueller S, Nicolaides T, Haas-Kogan D, Prados M, Banerjee A, Auguste KI, Gupta N. Childs Nerv Syst. 29(8):1313-9
2013 Management and outcome of focal low-grade brainstem tumors in pediatric patients: the St. Jude experience. Klimo P Jr, Pai Panandiker AS, Thompson CJ, Boop FA, Qaddoumi I, Gajjar A, Armstrong GT, Ellison DW, Kun LE, Ogg RJ, Sanford RA. J Neurosurg Pediatr 11(3):274-81
2013 Prognostic significance of telomere maintenance mechanisms in pediatric high-grade gliomas. Dorris K, Sobo M, Onar-Thomas A, Panditharatna E, Stevenson CB, Gardner SL, Dewire MD, Pierson CR, Olshefski R, Rempel SA, Goldman S, Miles L, Fouladi M, Drissi R. J Neurooncol. 117(1):67-76
2013 Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas. Paugh BS, Zhu X, Qu C, Endersby R, Diaz AK, Zhang J, Bax DA, Carvalho D, Reis RM, Onar-Thomas A, Broniscer A, Wetmore C, Zhang J, Jones C, Ellison DW, Baker SJ. Cancer Res. 73(20):6219-29
2013 Novel therapeutic delivery approaches in development for pediatric gliomas. Warren KE. CNS Oncol. 2(5):427-435
2013 PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma. Barton KL, Misuraca K, Cordero F, Dobrikova E, Min HD, Gromeier M, Kirsch DG, Becher OJ. PLoS One 8(10)
2013 Robot-guided convection-enhanced delivery of carboplatin for advanced brainstem glioma. Barua NU, Lowis SP, Woolley M, O'Sullivan S, Harrison R, Gill SS. Acta Neurochir (Wien) 155(8):1459-65
2013 A lesson learned from the H3.3K27M mutation found in pediatric glioma: a new approach to the study of the function of histone modifications in vivo? Chan KM, Han J, Fang D, Gan H, Zhang Z. Cell Cycle 12(16):2546-52
2013 Brain stem tumors in children and adolescents: single institutional experience. Garzón M, García-Fructuoso G, Guillén A, Suñol M, Mora J, Cruz O. Childs Nerv Syst. 29(8):1321-31
2013 Bereaved parents’ intentions and suggestions about research autopsies in children with lethal brain tumors. Baker JN, Windham JA, Hinds PS, Gattuso JS, Mandrell B, Gajjar P, West NK, Hammarback T, Broniscer A. J Pediatr. 163(2):581-6
2013 Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Lewis PW, Müller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA, Muir TW, Becher OJ, Allis CD. Science 340(6134):857-61
2013 A phase I trial of arsenic trioxide chemoradiotherapy for infiltrating astrocytomas of childhood. Cohen KJ, Gibbs IC, Fisher PG, Hayashi RJ, Macy ME, Gore L. Neuro Oncol. 15(6):783-7
2013 H3.3 G34R mutations in pediatric primitive neuroectodermal tumors of central nervous system (CNS-PNET) and pediatric glioblastomas: possible diagnostic and therapeutic implications? Gessi M, Gielen GH, Hammes J et al. J Neurooncol. 112:1 (67-72)
2013 Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN. Bjerke L, Mackay A et al. Cancer Discov.
2013 A multi-disciplinary consensus statement concerning surgical approaches to low-grade, high-grade astrocytomas and diffuse intrinsic pontine gliomas in childhood (CPN Paris 2011) using the Delphi method. Walker DA, Liu J, Kieran M et al. Neuro Oncol. 15:4 (462-8)
2013 Phase I Trial, Pharmacokinetics, and Pharmacodynamics of Vandetanib and Dasatinib in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma. Broniscer A, Baker SD, et al. Clin Cancer Res
2013 Brainstem glioma: a review. Grimm SA, Chamberlain MC. Curr Neurol Neurosci Rep 13:5 (346)
2013 MR Imaging Assessment of Tumor Perfusion and 3D Segmented Volume at Baseline, during Treatment, and at Tumor Progression in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma. Sedlacik J, Winchell A, Kocak M. et al. AJNR Am J Neuroradiol
2013 Bereaved Parents’ Intentions and Suggestions about Research Autopsies in Children with Lethal Brain Tumors. Baker JN, Windham JA, Hinds PS. et al. J Pediatr.
2012 Diffuse intrinsic pontine glioma: poised for progress. Warren KE. Front Oncol.
2012 Diffuse intrinsic pontine glioma (DIPG): time to biopsy again? MacDonald TJ Pediatr Blood Cancer 58:4 (487-8)
2012 Diffuse intrinsic pontine gliomas: new waves. Nishikawa R Neuro Oncol 14:3 (245)
2012 Expression of epidermal growth factor variant III (EGFRvIII) in pediatric diffuse intrinsic pontine gliomas Li G, Mitra SS, et al. J Neurooncol 108:3 (395-402) v. 109L3
2012 Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas Puget S, Philippe C, et al. PLoS One
2012 Single- and multivoxel proton spectroscopy in pediatric patients with diffuse intrinsic pontine glioma Steffen-Smith EA, Venzon DJ, et al. Int J Radiat Oncol Biol Phys 84:3 (774-9)
2012 Insights into pediatric diffuse intrinsic pontine glioma through proteomic analysis of cerebrospinal fluid Saratsis AM, Yadavilli S, et al. Neuro Oncol 14:5 (547-60)
2012 Biopsy of diffuse intrinsic pontine gliomas? Rutka JT J Neurosurg Pediatr 10:2 (79-80)
2012 Implementation of a Multi-Institutional Diffuse Intrinsic Pontine Glioma Autopsy Protocol and Characterization of a Primary Cell Culture Caretti V, Jansen MH, et al. Neuropathol Appl Neurobiol
2012 Aurora Kinase B Is a Potential Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma. Buczkowicz P, Zarghooni M, et al. Brain Pathol
2012 A new era for children with diffuse intrinsic pontine glioma: hope for cure Kaspers GJ, Jansen MH Expert Rev Anitcancer Ther 12:9 (1109-12)
2012 B7-H3, a potential therapeutic target, is expressed in diffuse intrinsic pontine glioma Zhou Z, Luther N, et al. J Neurooncol
2012 Convection-enhanced delivery of topotecan into diffuse intrinsic brainstem tumors in children Anderson RC, Kennedy B, et al. J Neurosurg Pediatr
2012 Prolonged survival after treatment of diffuse intrinsic pontine glioma with radiation, temozolamide, and bevacizumab: report of 2 cases. Aguilera DG, Mazewski C, et al. J Pediatr Hematol Oncol 35:1 (42-6)
2012 Children’s Oncology Group’s 2013 blueprint for research: Central nervous system tumors Gajjar A, Packer RJ, et al Pediatr Blood Cancer
2012 WEE1 Kinase Inhibition Enhances the Radiation Response of Diffuse Intrinsic Pontine Gliomas. Caretti V, Hiddingh L, et al. Mol Cancer Ther
2012 Overcoming Autopsy Barriers in Pediatric Cancer Research Alabran JL, Hooper JE, et al. Pediatr Blood Cancer 60:2 (204-9)
2012 K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas Khuong-Quang DA, Buczkowicz P, et al. Acta Neuropathol 124:3 (439-47)
2012 Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas Wu G, A Broniscer, TA McEachron, et al. Nat Genet
2012 Role of Early Postradiation Magnetic Resonance Imaging Scans in Children with Diffuse Intrinsic Pontine Glioma Ko C, A Kaushal, DA Hammoud, et al. Int J Radiat Oncol Biol Phys
2012 Diffuse intrinsic pontine gliomas: a systematic update on clinical trials and biology Jansen MH, DG van Vuurden, WP Vandertop, et al. Cancer Treat Rev 38:1 (27-35)
2012 Palliative reirradiation for progressive diffuse intrinsic pontine glioma Fontanilla HP, CC Pinnix, LM Ketonen, et al. Am J Clin Oncol 35:1 (51-7)
2012 Radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma Chassot A, S Canale, P Varlet, et al. J Neurooncol 106:2 (399-407)
2011 Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor Consortium Zukotynski KA, FH Fahey, M Kocak, et al. J Nucl Med 52:2 (188-95)
2011 Magnetic resonance spectroscopic detection of lactate is predictive of a poor prognosis in patients with diffuse intrinsic pontine glioma Yamasaki F, K Kurisu, Y Kajiwara, et al. Neuro Oncol 13:7 (791-801)
2011 Genomic aberrations in pediatric diffuse intrinsic pontine gliomas Warren KE, K Killian, M Suuriniemi, et al. Neuro Oncol
2011 A phase 2 study of pegylated interferon alpha-2b (PEG-Intron(R)) in children with diffuse intrinsic pontine glioma Warren K, R Bent, PL Wolters, et al. Cancer
2011 Proton magnetic resonance spectroscopy predicts survival in children with diffuse intrinsic pontine glioma Steffen-Smith EA, JH Shih, SJ Hipp, et al. J Neurooncol 105:2 (365-73)
2011 Prospective neuraxis MRI surveillance reveals a high risk of leptomeningeal dissemination in diffuse intrinsic pontine glioma Sethi R, J Allen, B Donahue, et al. J Neurooncol 102:1 (121-7)
2011 DTI assessment of the brainstem white matter tracts in pediatric BSG before and after therapy: a report from the Pediatric Brain Tumor Consortium Prabhu SP, S Ng, S Vajapeyam, et al. Childs Nerv Syst 27:1 (39759)
2011 MRI as a central component of clinical trials analysis in brainstem glioma: a report from the Pediatric Brain Tumor Consortium (PBTC) Poussaint TY, M Kocak, S Vajapeyam, et al. Neuro Oncol 13:4 (417-27)
2011 A phase II study of gefitinib and irradiation in children with newly diagnosed brainstem gliomas: a report from the Pediatric Brain Tumor Consortium Pollack IF, CF Stewart, M Kocak, et al. Neuro Oncol 13:3 (290-7)
2011 Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma Paugh BS, A Broniscer, C Qu, et al. J Clin Oncol 29:30 (3999-4006)
2011 Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma Monje M, SS Mitra, ME Freret, et al. Proc Natl Acad Sci U S A 108:11 (4453-8)
2011 Nimotuzumab for pediatric diffuse intrinsic pontine gliomas Massimino M, U Bode, V Biassoni, et al. Expert Opin Biol Ther 11:2 (247-56)
2011 Quantitative diffusion-weighted and dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging analysis of T2 hypointense lesion components in pediatric diffuse intrinsic pontine glioma Lobel U, J Sedlacik, WE Reddick, et al. AJNR Am J Neuroradiol 32:2 (315-22)
2011 Diffuse intrinsic pontine glioma-current status and future strategies Khatua S, KR Moore, TS Vats, et al. Childs Nerv Syst 27:9 (1391-7)
2011 Predicting outcome of children with diffuse intrinsic pontine gliomas using multiparametric imaging Hipp SJ, E Steffen-Smith, D Hammoud, et al. Neuro Oncol 13:8 (904-9)
2011 Molecular genetic approaches and potential new therapeutic strategies for pediatric diffuse intrinsic pontine glioma Hawkins CE, U Bartels, E Bouffet J Clin Oncol 29:30 (3956-7)
2011 Phase II trial of tipifarnib and radiation in children with newly diagnosed diffuse intrinsic pontine gliomas Haas-Kogan DA, A Banerjee, TY Poussaint, et al. Neuro Oncol 13:3 (298-306)
2012 Critical oncogenic mutations in newly diagnosed pediatric diffuse intrinsic pontine glioma Grill J, S Puget, F Andreiuolo, et al. Pediatr Blood Cancer 58:4 (489-91)
2011 Innovative Therapies for Children with Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors Geoerger B, D Hargrave, F Thomas, et al. Neuro Oncol 13:1 (109-18)
2011 Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: a report from the Children’s Oncology Group Cohen KJ, RL Heideman, T Zhou, et al. Neuro Oncol 13:4 (410-6)
2011 Proceedings of the diffuse intrinsic pontine glioma (DIPG) Toronto Think Tank: advancing basic and translational research and cooperation in DIPG Bartels U, C Hawkins, G Vezina, et al. J Neurooncol 105:1 (119-25)
2011 Post mortem examinations in diffuse intrinsic pontine glioma: challenges and chances Angelini P, C Hawkins, N Laperriere, et al. J Neurooncol 101:1 (75-81)
2010 Whole-genome profiling of pediatric diffuse intrinsic gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets Zarghooni M, U Bartels, E Lee, et al. J Clin Oncol 28:8 (1337-44)
2010 Establishment of a human glioblastoma stemlike brainstem rodent tumor model Siu IM, BM Tyler, JX Chen, et al. J Neurosurg Pediatr 6:1 (92-7)
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2010 Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease Paugh BS, C Qu, C Jones, et al. J Clin Oncol 28:18 (3061-8)
2010 The addition of high-dose tamoxifen to standard radiotherapy does not improve the survival of patients with diffuse intrinsic pontine glioma Michalski A, E Bouffet, RE Taylor, et al. J Neurooncol 100:1 (81-8)
2010 Prospective evaluation of radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma Jalali R, N Raut, B Arora, et al. Int J Radiat Oncol Biol Phys 77:1 (113-8)
2010 Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: a Pediatric Brain Tumor Consortium study Gururangan S, SN Chi, T Young Poussaint, et al. J Clin Oncol 28:18 (3069-75)
2010 Phase I study of vandetanib during and after radiotherapy in children with diffuse intrinsic pontine glioma Broniscer A, JN Baker, M Tagen, et al. J Clin Oncol 28:31 (4762-8)
2010 Prospective collection of tissue samples at autopsy in children with diffuse intrinsic pontine glioma Broniscer A, JN Baker, SJ Baker, et al. Cancer 116:19 (4632-7)
2009 Conventional MRI at presentation does not predict clinical response to radiation therapy in children with diffuse pontine glioma Liu AK, J Brandon, NK Foreman, et al. Pediatr Radiol 39:12 (1317-20)
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2008 Diffuse intrinsic brainstem tumors in neonates. Report of two cases Shah NC, A Ray, U Bartels, et al. J Neurosurg Pediatr 1:5 (382-5)
2008 Protein profiling of formalin fixed paraffin embedded tissue: Identification of potential biomarkers for pediatric brainstem glioma Nazarian J, M Santi, Y Hathout, et al. Proteomics Clin Appl 2:6 (915-24)
2008 Diffuse pontine gliomas in children: changing strategies, changing results? A mono-institutional 20-year experience Massimino M, F Spreafico, V Biassoni, et al. J Neurooncol 87:3 (355-61)
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2008 Conventional MRI cannot predict survival in childhood diffuse intrinsic pontine glioma Hargrave D, N Chuang, E Bouffet J Neurooncol 86:3 (313-9)
2008 Preradiation chemotherapy may improve survival in pediatric diffuse intrinsic brainstem gliomas: final results of BSG 98 prospective trial Frappaz D, M Schell, P Thiesse, et al. Neuro Oncol 10:4 (599-607)
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2007 Phase II study of thalidomide and radiation in children with newly diagnosed brain stem gliomas and glioblastoma multiforme Turner CD, S Chi, KJ Marcus, et al. J Neurooncol 82:1 (95-101)
2007 Magnetic resonance imaging compared with biopsy in the diagnosis of brainstem diseases of childhood: a multicenter review Schumacher M, J Schulte-Monting, P Stoeter, et al. J Neurosurg 106:2 Suppl (111-9)
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2015 Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Grasso CS, Tang Y, Truffaux N, Berlow NE, Liu L, Debily MA, Quist MJ, Davis LE, Huang EC, Woo PJ, Ponnuswami A, Chen S, Johung TB, Sun W, Kogiso M, Du Y, Qi L, Huang Y, Hütt-Cabezas M, Warren KE, Le Dret L, Meltzer PS, Mao H, Quezado M, van Vuurden DG, Abraham J, Fouladi M, Svalina MN, Wang N, Hawkins C, Nazarian J, Alonso MM, Raabe EH, Hulleman E, Spellman PT, Li XN, Keller C, Pal R, Grill J, Monje M. Nat Med. 21(6):555-9